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December 8, 2025BloodOpen Access

Impact of recipient sociodemographic factors on allogeneic transplant conditioning intensity and survival outcomes in myeloid malignancies: A secondary analysis of CIBMTR data

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Authors

ATAllison O. TaylorSWSteven WolfTLThomas Leblanc

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Overview

Secondary analysis shows treatment outcomes are linked to clinical factors, not sociodemographics, in myeloid malignancies.

Key Points

  • Higher Karnofsky Performance Status scores and younger age were associated with enhanced treatment options.
  • Patients with acute myeloid leukemia demonstrated better progression free survival compared to those with chronic conditions.
  • Assessment utilized public CIBMTR dataset analyzing sociodemographic impact on treatment decisions across 125 centers.
  • Treatment decisions appear influenced by clinical aspects, minimizing the effect of sociodemographic factors on mortality.

Cite This Study

Taylor et al. (2025) studied this question.

synapsesocial.com/papers/69362f4b4fa91c937236d800https://doi.org/10.1182/blood-2025-2841
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Conditioning intensity and post-transplant outcomes in acute myeloid leukemia: A real-world analysis.2026
  2. 2Conditioning intensity in myelodysplastic patients aged ≥ 50 years undergoing allogeneic hematopoietic cell transplantation (allo-HCT): a study on behalf of the chronic malignancies working party of the EBMT2025 · 2 citations
  3. 3Impacts of IPSS-m and conditioning intensity in allogeneic hematopoietic cell transplant for patients with myelodysplasia neoplasms2025
  4. 4Outcomes of myeloablative vs reduced and non-myeloablative conditioning in MRD-negative AML and ALL with ptcy-based GVHD prophylaxis2025
  5. 5Can we move beyond myeloablative conditioning ( MAC )? A comparison of MAC versus reduced intensity conditioning ( RIC ) in patients aged younger than 65 years undergoing allogeneic haematopoietic cell transplantation using ATG ‐ PTCy ‐ CSA for GVHD prophylaxis2025 · 2 citations