Conditioning intensity in myelodysplastic patients aged ≥ 50 years undergoing allogeneic hematopoietic cell transplantation (allo-HCT): a study on behalf of the chronic malignancies working party of the EBMT
Retrospective study compares reduced intensity versus myeloablative conditioning in elderly MDS patients, indicating no significant outcome differences.
Key Points
There was no significant association between conditioning intensity and patient outcomes after allo-HCT.
Among 1393 patients, 75.5% received reduced intensity conditioning, with a median follow-up of 27.9 months.
Both univariate and multivariate analyses yielded no significant outcomes based on conditioning regimens used.
The findings align with a recent systematic review that suggests weak evidence for favoring one conditioning regimen over another.