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May 11, 2026Molecular BiomedicineOpen Access

Transition from acute kidney injury to chronic kidney disease: molecular mechanisms and therapeutic interventions

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Authors

XHX Y HuangMWM.M. WangBYBinfeng Yu

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Overview

Systematic analysis uncovers molecular pathways linking acute kidney injury to chronic kidney disease, indicating novel therapeutic targets.

Key Points

  • This research aims to elucidate the molecular mechanisms driving the transition from acute kidney injury (AKI) to chronic kidney disease (CKD).
  • Systematic dissection of pathological mechanisms related to AKI-CKD transition, focusing on unique cell states and interactions.
  • Utilization of single-cell and spatial omics technologies to identify key signaling pathways and cellular changes.
  • Exploration of therapeutic interventions targeting maladaptive signaling and fibrotic pathways.
  • Documented persistent cell cycle arrest and cellular senescence contribute to the AKI-CKD transition.
  • Characterized activation of TGF-β/Smad, Wnt/β-catenin, and Hedgehog signaling pathways as central to the process.
  • Proposed novel biomarkers and imaging strategies for early diagnosis and intervention.

Cite This Study

Huang et al. (2026) studied this question.

synapsesocial.com/papers/6a0171ce3a9f334c28271e56https://doi.org/10.1186/s43556-026-00462-z
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Role of the TGF‑β/Smad signaling pathway in the transition from acute kidney injury to chronic kidney disease (Review)2025
  2. 2Discovery Pipeline for AKI: Molecules, Mechanisms, Models, and Targets2025
  3. 3Epigenetic memories induced by hypoxia in AKI-to-CKD transition2025
  4. 4From acute kidney injury to chronic kidney disease in children: maladaptive repair and the need for long-term surveillance - a literature review2025
  5. 5Acute kidney injury: pathogenesis and therapeutic interventions2025