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July 31, 2025International Journal of Molecular Medicine

Role of the TGF‑β/Smad signaling pathway in the transition from acute kidney injury to chronic kidney disease (Review)

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Authors

YZYuanxia ZouJDJian S. DaiJLJianchun Li

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Overview

Review reveals TGF-β/Smad pathway's impact on renal fibrosis in acute kidney injury, suggesting new therapeutic strategies.

Key Points

  • The TGF-β/Smad signaling pathway is crucial for understanding the transition from acute kidney injury to chronic kidney disease.
  • Activation of the pathway promotes tubular cell injury and interstitial fibrosis after acute kidney injury.
  • Recent findings demonstrate the pathway's role in inflammation and fibrotic changes associated with kidney damage.
  • Insights gained may lead to novel therapies that target the TGF-β/Smad pathway to prevent chronic kidney disease progression.

Cite This Study

Zou et al. (2025) studied this question.

synapsesocial.com/papers/689a094be6551bb0af8cf315https://doi.org/10.3892/ijmm.2025.5603
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Transition from acute kidney injury to chronic kidney disease: molecular mechanisms and therapeutic interventions2026 · 2 citations
  2. 2The pivotal role of TGF-β/Smad pathway in fibrosis pathogenesis and treatment2025 · 65 citations
  3. 3Ablation of the renal tubular gluconeogenic enzyme PCK1 drives AKI-to-CKD transition by negatively regulating the TGF-β/Smad3 signaling pathway2026
  4. 4Molecular Basis of Oxidative Stress-Induced Acute Kidney Injury, Kidney Fibrosis, Chronic Kidney Disease, and Clinical Significance of Targeting Reactive Oxygen Species-Regulated Pathways to Treat Kidney Disease2025
  5. 5Discovery Pipeline for AKI: Molecules, Mechanisms, Models, and Targets2025