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December 2, 2025˜The œNephron journals/Nephron journals

Discovery Pipeline for AKI: Molecules, Mechanisms, Models, and Targets

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Authors

TCTanima ChatterjeeJRJoseph RutkowskiDSDanielle E Soranno

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Overview

Emerging research reveals critical roles of molecular networks in acute kidney injury, suggesting novel therapeutic targets for disease management.

Key Points

  • Acute kidney injury highlights the importance of understanding therapeutic targets for improved clinical outcomes.
  • Macrophage regulation and synuclein-⍺ involvement were key aspects of the ongoing research in AKI.
  • Analysis incorporated mechanosensitive ion channels and the cholinergic anti-inflammatory pathway for nephroprotection.
  • Understanding molecular networks in AKI may enable transformative approaches for managing kidney disease.

Cite This Study

Chatterjee et al. (2025) studied this question.

synapsesocial.com/papers/692e3da16c9b3ab28c187bb5https://doi.org/10.1159/000549795
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Acute kidney injury: pathogenesis and therapeutic interventions2025
  2. 2Transition from acute kidney injury to chronic kidney disease: molecular mechanisms and therapeutic interventions2026 · 2 citations
  3. 3The evolving landscape of acute kidney injury: research directions and changes in clinical practice2026
  4. 4Molecular mechanisms and therapeutic advances of peritubular capillary neogenesis in acute kidney injury2025
  5. 5Mitochondrial dysfunction and metabolic reprogramming in acute kidney injury: mechanisms, therapeutic advances, and clinical challenges2025