Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
August 20, 2025Clinical and Experimental NephrologyOpen Access

Epigenetic memories induced by hypoxia in AKI-to-CKD transition

View Full Paper
Ask AI
Bookmark
Share

Authors

GKGiyoung KwounMNMasaomi NangakuIMImari Mimura

Discussion

Loading...

Member takes

Overview

Observational analysis highlights epigenetic changes in AKI survivors, suggesting new strategies to combat CKD.

Key Points

  • Persistent epigenetic changes during the AKI-to-CKD transition drive increased fibrosis, impacting kidney health.
  • Evidence shows epigenetic alterations from hypoxia, including DNA methylation and histone changes, contribute to CKD's progression.
  • Reviewing recent findings on epigenetic memory reveals potential therapeutic targets in kidney disease management.
  • Understanding the temporal specificity of epigenetic changes may enable more effective treatments in chronic kidney disease.

Cite This Study

Kwoun et al. (2025) studied this question.

synapsesocial.com/papers/68af409acf1dd9ea359ec732https://doi.org/10.1007/s10157-025-02745-1
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Transition from acute kidney injury to chronic kidney disease: molecular mechanisms and therapeutic interventions2026 · 2 citations
  2. 2The Association of Acute Kidney Injury with the Development and Progression of Chronic Kidney Disease: A Systematic Review2025
  3. 3From Metabolic to Epigenetic Memory: The Impact of Hyperglycemia-Induced Epigenetic Signature on Kidney Disease Progression and Complications2025
  4. 4From Metabolic to Epigenetic Memory: The Impact of Hyperglycemia-Induced Epigenetic Signature on Kidney Disease Progression and Complications2025
  5. 5The Impact of Epigenomics on Understanding Kidney Diseases2025