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December 8, 2025Blood

A single cell multiomic approach to dissect immunophenotypic plasticity in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) pediatric patients

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Authors

FLFranco Locatelli

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Overview

Single-cell analysis reveals transcriptional and epigenetic mechanisms of plasticity in pediatric acute lymphoblastic leukemia, indicating differentiation dynamics in bone marrow.

Key Points

  • Differential abundance of cells indicates immature phenotype in pediatric acute lymphoblastic leukemia.
  • Single-cell multiomic profiling shows transcriptional changes by day 15 during induction therapy.
  • Analysis of bone marrow samples reveals distinct methylation patterns in DNA at diagnosis.
  • Findings suggest that plasticity in acute lymphoblastic leukemia is linked to specific molecular mechanisms.

Cite This Study

Franco Locatelli (2025) studied this question.

synapsesocial.com/papers/69362f7f4fa91c937236e5f2https://doi.org/10.1182/blood-2025-36
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  4. 4Integrated multi-omic analysis reveals novel subtype-specific regulatory interactions in pediatric B-cell acute lymphoblastic leukemia2025
  5. 5Spatial single-cell multiomics of the bone marrow microenvironment in NPM1-mutant Acute Myeloid Leukemia2025