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December 8, 2025Blood

Multi-omics single-cell spatial profiling of paediatric and adult acute myeloid leukaemia links spatial organization, molecular genetics and microenvironmental interactions

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Authors

MMMerel van der MeulenEPEmma S. PoolLPLivius Penter

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Overview

Multi-omics analysis reveals spatial organization and interactions in acute myeloid leukaemia, highlighting roles of macrophages and stromal cells.

Key Points

  • AML patients demonstrate distinct cellular interactions within the bone marrow microenvironment, impacting treatment strategies.
  • Using spatial transcriptomics, researchers identified unique microenvironments and cell types across leukemia samples, offering insights into immune evasion.
  • Observational analysis of acute myeloid leukaemia tissue biopsies provided a multi-omics view integrating single-cell RNA sequencing and spatial proteomics data.
  • These findings highlight the importance of cellular neighbourhoods in AML, suggesting potential therapeutic targets through microenvironmental crosstalk.

Cite This Study

Meulen et al. (2025) studied this question.

synapsesocial.com/papers/69362f4b4fa91c937236d754https://doi.org/10.1182/blood-2025-860
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  1. 1Spatial single-cell multiomics of the bone marrow microenvironment in NPM1-mutant Acute Myeloid Leukemia2025
  2. 2Dynamics of leukemic blast and immune cell populations in Acute Myeloid Leukemia2025
  3. 3Multi-omics integration reveals therapeutic vulnerabilities and immune microenvironment subtypes in Acute Myeloid Leukemia2025 · 1 citations
  4. 4Single-cell multi-omics uncovers differentiation-dependent transcriptional programs shaping epigenetic subgroups in AML2025
  5. 5Characterising the leukaemic microenvironment in a mouse model of infant AML with prenatal KMT2A-MLLT3 expression2025