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November 30, 2025Cancer Research CommunicationsOpen Access

Cell state transitions drive the evolution of disease progression in B-lymphoblastic leukemia

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Authors

CGCurtis GravenmierSMSadegh MarzbanYTYi-Han Tang

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Overview

Analysis reveals cancer stem cells influence minimal residual disease in B-lymphoblastic leukemia, suggesting new therapeutic strategies.

Key Points

  • Presence of cancer stem cells correlates with high chemoresistance levels in B-lymphoblastic leukemia, affecting prognosis.
  • Mathematical model demonstrates how transitions across immunophenotypes impact minimal residual disease management.
  • Assessment using flow cytometry reveals critical insights into hematopoietic stem cell dynamics and disease progression.
  • Blocking dedifferentiation from a stem cell-like state may enhance treatment efficacy for relapsed patients with acute myeloid leukemia.

Cite This Study

Gravenmier et al. (2025) studied this question.

synapsesocial.com/papers/692b943e1d383f2b2a3789d4https://doi.org/10.1158/2767-9764.crc-25-0277
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract B035: Cell state transitions drive the evolution of disease progression in B-lymphoblastic leukemia2025
  2. 2Alternating cycles of quiescent and proliferative cell states determine stemness and leukemia-initiation capacity in acute lymphoblastic leukemia2025
  3. 3Chemotherapy selects for myeloid subclones in multiple subtypes of B-cell acute lymphoblastic leukemia2025
  4. 4Chronic myeloid leukemia (CML) evolution is not encoded in single-cell microstates, but emerges from population-level macrostates2025
  5. 5A collective non-mutational transition governs the development of chronic myeloid leukemia2025