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December 8, 2025Blood

Chemotherapy selects for myeloid subclones in multiple subtypes of B-cell acute lymphoblastic leukemia

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Authors

CCChangya Chen

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Overview

Analysis reveals chemotherapy-induced myeloid subclones in pediatric B-ALL, suggesting implications for blinatumomab therapy.

Key Points

  • Myeloid subclones show resistance to therapy, impacting treatment outcomes for B-cell acute lymphoblastic leukemia.
  • Resistant subclones identified via single-cell DNA-seq, highlighting concerns for patient classification and treatment decisions.
  • Multiomic profiling utilized to unveil lineage plasticity and subclone characteristics in leukemia samples.
  • Identifying stem cell markers at residual disease could optimize treatment strategies targeting myeloid populations.

Cite This Study

Changya Chen (2025) studied this question.

synapsesocial.com/papers/69362f7f4fa91c937236e5eehttps://doi.org/10.1182/blood-2025-35
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Multiple Lineage Switches in a Pediatric Case With a KMT2A::AFF1‐Positive Acute Lymphoblastic Leukemia: How Cell Plasticity Induces Immunotherapy Failure2025 · 1 citations
  2. 2Multi-omic analysis of early minimal residual disease identifies functional and transcriptomic signatures of treatment resistance in pediatric B-cell acute lymphoblastic leukemia2025
  3. 3Lineage switch of adult B-cell acute lymphoblastic leukaemia to acute myeloid leukaemia following B-cell-directed therapy2025 · 2 citations
  4. 4A single cell multiomic approach to dissect immunophenotypic plasticity in B-cell precursor acute lymphoblastic leukemia (BCP-ALL) pediatric patients2025
  5. 5Baseline T-cell fitness and subtype-specific CD19 loss as drivers of blinatumomab resistance in B-ALL2025