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December 8, 2025BloodOpen Access

Integrated single-cell and spatial analysis identifies T cell exhaustion and adhesion signatures in early follicular lymphoma transformation

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Authors

PAPaula Aguirre‐RuizAPAna Alfonso PiérolaEPEsther Pena

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Overview

Single-cell RNA sequencing reveals distinct T cell exhaustion and adhesion signatures in follicular lymphoma, suggesting immunosuppressive mechanisms at play.

Key Points

  • Exhaustion markers are significantly higher in CD8+ Teff and CD4+ Treg cells in transformed follicular lymphoma cases.
  • Single-cell RNA sequencing identified cytokine signaling genes overexpressed in non-transformed follicular lymphoma B cells.
  • Analysis included single-cell and spatial transcriptomics from lymph node samples to understand tumor microenvironment interactions.
  • Findings imply distinct biological entities exist between non-transformed and transformed follicular lymphoma, with prognostic implications.

Cite This Study

Aguirre‐Ruiz et al. (2025) studied this question.

synapsesocial.com/papers/69362f7f4fa91c937236e580https://doi.org/10.1182/blood-2025-3539
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Longitudinal single-cell profiling of the bone marrow heterogeneity identifies the T-cell niche supporting cancer persister cells in follicular lymphoma2025
  2. 2Intratumoral B cell diversity in follicular lymphoma revealed by single-cell paired transcriptome and BCR sequencing2025
  3. 3Single-cell analysis and functional profiling reveal galectin-3–driven reprogramming of the tumor immune microenvironment in transformed follicular lymphoma2025
  4. 4RAG1/2 expression in follicular lymphoma marks candidate precursor cells of high-grade B cell lymphoma with MYC and BCL2 rearrangements2025
  5. 5Spatial transcriptomic analysis of chronic lymphocytic leukemia lymph nodes reveals tumor microenvironment evolution during disease progression2025