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December 8, 2025BloodOpen Access

Intratumoral B cell diversity in follicular lymphoma revealed by single-cell paired transcriptome and BCR sequencing

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Authors

JWJanek S. WalkerZYZhi-Zhang YangMMMatthew J. Maurer

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Overview

Single-cell sequencing reveals diverse B cell populations in follicular lymphoma, suggesting complex tumor microenvironment interactions.

Key Points

  • B cell populations exhibit transcriptional diversity impacting tumor biology and immune response.
  • Malignant B cells showed higher expression of BCL2, influencing proliferation and survival.
  • Differential expression analysis identified distinct gene signatures across B cell populations.
  • These findings highlight the complexity of follicular lymphoma, with implications for treatment strategies.

Cite This Study

Walker et al. (2025) studied this question.

synapsesocial.com/papers/69362f5a4fa91c937236db38https://doi.org/10.1182/blood-2025-5342
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Longitudinal single-cell profiling of the bone marrow heterogeneity identifies the T-cell niche supporting cancer persister cells in follicular lymphoma2025
  2. 2Integrated single-cell and spatial analysis identifies T cell exhaustion and adhesion signatures in early follicular lymphoma transformation2025
  3. 3Whole-genome sequencing reveals three follicular lymphoma subtypes with distinct cell of origin and patient outcomes2025 · 3 citations
  4. 4Closing the gap: Genetic profiling of B-cell lymphomas using integrative whole-exome and whole-transcriptome sequencing2025
  5. 5Molecular distinctiveness of duodenal-type follicular lymphoma revealed by integrated multi-omic analysis2025