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December 8, 2025BloodOpen Access

Single-cell analysis and functional profiling reveal galectin-3–driven reprogramming of the tumor immune microenvironment in transformed follicular lymphoma

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Authors

HZHuilai Zhang

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Overview

Single-cell analysis reveals galectin-3 drives immune evasion and suppression in follicular lymphoma, suggesting new immunotherapy strategies.

Key Points

  • This research aims to investigate the tumor immune microenvironment in transformed follicular lymphoma and the role of galectin-3 in immune suppression.
  • Conducted single-cell RNA sequencing to analyze the tumor immune microenvironment of follicular lymphoma and transformed follicular lymphoma.
  • Validated findings with multiplex immunofluorescence staining, in vitro assays, and a mouse xenograft model.
  • Compared proportions of exhausted CD8+ T cells and their checkpoint receptors in transformed versus non-transformed cases.
  • Transformed follicular lymphoma patients show increased CD8+ T cell exhaustion with higher levels of checkpoint receptors.
  • Galectin-3 enhances interactions with CD8+ T cells, leading to immune suppression.
  • Treatment with the Galectin-3 inhibitor GB1107 restores T cell function and reduces immune evasion.

Cite This Study

Huilai Zhang (2025) studied this question.

synapsesocial.com/papers/693624d74fa91c937236d116https://doi.org/10.1182/blood-2025-5033
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Integrated single-cell and spatial analysis identifies T cell exhaustion and adhesion signatures in early follicular lymphoma transformation2025
  2. 2Integrative multi-omics reveals a regulatory and exhausted T-cell landscape in CLL and identifies galectin-9 as an immunotherapy target2025 · 26 citations
  3. 3Longitudinal single-cell profiling of the bone marrow heterogeneity identifies the T-cell niche supporting cancer persister cells in follicular lymphoma2025
  4. 4[Galectin-3 in the Lung Cancer Microenvironment: Immunomodulation and Therapeutic Breakthroughs].2025
  5. 5FLT3L combined with GM-CSF induced dendritic cells drive broad tumor-specific CD8+ T cell responses and remodel the tumor microenvironment to enhance anti-tumor efficacy2025 · 6 citations