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December 8, 2025Blood

RAG1/2 expression in follicular lymphoma marks candidate precursor cells of high-grade B cell lymphoma with MYC and BCL2 rearrangements

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Authors

GMGaia MorelloVPVilma PellegriniMPMaurilio Ponzoni

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Overview

Observational analysis shows RAG1/2 expression in follicular lymphoma identifies putative precursor cells for aggressive high-grade B cell lymphoma.

Key Points

  • RAG1/2 expression marks a subset of follicular lymphoma cases linked to high-grade B cell lymphoma.
  • Eighty-three percent of analyzed follicular lymphoma cases revealed RAG1/2 expression anticipating transformation to high-grade lymphoma.
  • Analysis involved immunohistochemistry alongside RNA scope and DNA FISH to localize precursor B cells within tissues.
  • Findings suggest RAG-positive cells in follicular lymphoma may serve as biomarkers for high-grade B cell lymphoma progression.

Cite This Study

Morello et al. (2025) studied this question.

synapsesocial.com/papers/69362f7f4fa91c937236e57dhttps://doi.org/10.1182/blood-2025-3534
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Stepwise engineering of human germinal center B cells to model dark zone high-grade B cell lymphoma driven by sequential BCL2 and MYC deregulation2025
  2. 2Clinical outcomes, patterns of relapse and molecular landscape of advanced stage High Grade B-cell Lymphoma2026
  3. 3Integrated single-cell and spatial analysis identifies T cell exhaustion and adhesion signatures in early follicular lymphoma transformation2025
  4. 4Clinicopathological characteristics of high-grade B-cell lymphomas through  Bone marrow evaluation2025
  5. 5Longitudinal single-cell profiling of the bone marrow heterogeneity identifies the T-cell niche supporting cancer persister cells in follicular lymphoma2025