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December 8, 2025BloodOpen Access

Spatial transcriptomic analysis of chronic lymphocytic leukemia lymph nodes reveals tumor microenvironment evolution during disease progression

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Authors

GNGiulia NotarpietroRDRossana DaprileASAnna Scattone

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Overview

Spatial transcriptomic analysis shows CLL-TME interactions evolve as macrophages and tumor cells change through disease stages, indicating important therapeutic targets.

Key Points

  • Tumor microenvironment displayed distinct transcriptional profiles linked to disease progression in chronic lymphocytic leukemia.
  • Macrophages and T lymphocytes showed altered gene expression patterns as disease advanced, emphasizing changes in immune status.
  • Digital spatial profiling allowed characterization of tumor cells and immune components in chronic lymphocytic leukemia lymph nodes.
  • Alterations in the tumor microenvironment and immune profiles highlight potential targets for therapeutic intervention.

Cite This Study

Notarpietro et al. (2025) studied this question.

synapsesocial.com/papers/69362f4e4fa91c937236d862https://doi.org/10.1182/blood-2025-3880
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Role of the immune microenvironment in the clonal evolution of chronic lymphocytic leukemia2025
  2. 2Single-nucleus dissection of peripheral T-cell lymphomas reveals distinct microenvironmental ecosystems and therapeutic vulnerabilities2025
  3. 3Spatial Analysis of the Tumor Microenvironment in Diffuse Large B-Cell Lymphoma Reveals Clinically Relevant Cell Interactions and Recurrent Cellular Neighborhoods2025 · 3 citations
  4. 4Morphology guided spatial transcriptomics to study topography of Hodgkin reed sternberg cells interaction with tumor microenvironment and its impact in defining risk of progression in classical Hodgkin lymphoma.2025
  5. 5Data from Spatial Analysis of the Tumor Microenvironment in Diffuse Large B-cell Lymphoma Reveals Clinically Relevant Cell Interactions and Recurrent Cellular Neighborhoods2025