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December 8, 2025BloodOpen Access

The role of microbial metabolites in fecal microbiota transplantation in patients with acute gvhd of the gut

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Authors

PHPeter HerhausMVMareike VerbeekKNKlaus Neuhaus

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Overview

Observational analysis reveals altered microbial metabolites in gut, indicating FMT may improve graft-versus-host disease response.

Key Points

  • Higher levels of specific immune-modulatory metabolites associated with better response to fecal microbiota transplantation.
  • A multicentric cohort study analyzed stool metabolites and microbiome diversity in 18 patients post-alloSCT.
  • Metagenomic sequencing and targeted mass spectrometry characterized shifts in the gut microbiome and metabolites.
  • Findings support the need for optimizing FMT protocols to enhance outcomes in graft-versus-host disease.

Cite This Study

Herhaus et al. (2025) studied this question.

synapsesocial.com/papers/69362f694fa91c937236defehttps://doi.org/10.1182/blood-2025-4236
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