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December 8, 2025BloodOpen Access

Poor nutritional intake prior to allogeneic hematopoietic cell transplantation is associated with higher incidence of lower-gastrointestinal graft-versus-host disease

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Authors

AGAntonio L. C. GomesSMSally MokhtariCCClaire Chappuis

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Overview

Observational analysis shows poor nutritional intake correlates with higher lower GI GVHD incidence, suggesting dietary intervention may improve outcomes.

Key Points

  • Lower GI graft-versus-host disease risk significantly increases with inadequate caloric and protein intake during allo-HCT.
  • Dietitians recorded that patients consumed less than 90% of energy needs over most of their allo-HCT admission, posing risks to outcomes.
  • Analysis of microbiome showed that higher baseline intake improved alpha diversity and reduced dominance by harmful bacteria.
  • Potential therapeutic interventions focusing on nutrition could improve microbiome health and transplant success in patients.

Cite This Study

Gomes et al. (2025) studied this question.

synapsesocial.com/papers/69362f634fa91c937236ddfahttps://doi.org/10.1182/blood-2025-4250
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