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July 29, 2025Journal of Translational MedicineOpen Access

“The microbiome in graft-versus-host disease: a tale of two ecosystems”

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Authors

HSHamed Soleimani SamarkhazanSNSina NouriMMMohsen Maleknia

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Overview

Narrative review reveals how microbiome dysbiosis and donor microbiota influence GVHD outcomes, suggesting targeted microbiome therapies may improve HSCT strategies.

Key Points

  • Graft-versus-host disease is affected by the interplay between recipient dysbiosis and donor microbiota.
  • Pre-transplant treatments can cause dysbiosis, leading to inflammation and worsening GVHD symptoms.
  • Therapies like probiotics and fecal microbiota transplantation show potential in restoring microbial balance.
  • Understanding the microbiome's role could lead to improved management strategies for patients undergoing HSCT.

Cite This Study

Samarkhazan et al. (2025) studied this question.

synapsesocial.com/papers/689a093fe6551bb0af8cec1fhttps://doi.org/10.1186/s12967-025-06797-5
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