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December 8, 2025Blood

Longitudinal and integrated analysis of oral and stool microbiome in allogeneic hematopoietic cell transplantation recipients.

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Authors

MGMonalisa GhoshDKDarren KingSCSung Won Choi

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Overview

Longitudinal analysis reveals decreased microbial diversity impacts graft-versus-host-disease outcomes in patients.

Key Points

  • Graft-versus-host-disease significantly affects microbiome diversity in allo-HCT patients, impacting survival.
  • Pre-transplant microbial diversity correlates with better patient outcomes, while diversity decreases post-transplant.
  • Assessment included longitudinal evaluations through multiple timepoints using samples from 27 patients over 6 months.
  • Findings highlight the need for targeted interventions to maintain microbiome diversity in allo-HCT patients.

Cite This Study

Ghosh et al. (2025) studied this question.

synapsesocial.com/papers/69362f4e4fa91c937236d876https://doi.org/10.1182/blood-2025-4225
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