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December 8, 2025BloodOpen Access

Good report of secondary allogeneic hematopoietic stem cell transplantation in patients with refractory/relapsed Acute Myeloid Leukemia

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Authors

TWTong WuQWQi WangYZYongqiang Zhao

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Overview

Retrospective analysis reveals 46.4% 2-year survival after secondary allogeneic transplantation in AML, highlighting viable post-relapse options.

Key Points

  • Eighteen patients (42%) achieved leukemia-free survival after secondary transplantation, indicating the potential effectiveness of the approach.
  • The median time for granulocyte engraftment was 14 days, showcasing rapid recovery in transplant patients.
  • Post-transplant complications included several viral infections with a notable need for careful monitoring and management.
  • With a focus on CR prior to transplant, this approach supports improved survival rates in patients with relapsed Acute Myeloid Leukemia.

Cite This Study

Wu et al. (2025) studied this question.

synapsesocial.com/papers/69362f744fa91c937236e2eahttps://doi.org/10.1182/blood-2025-7795
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Outcomes after a second allogeneic haematopoietic stem cell transplant for relapsed paediatric acute myeloid leukaemia improved over time: A study from the <scp>EBMT</scp> Paediatric Diseases Working Party2025 · 1 citations
  2. 2Multiple Hematopoietic Stem Cell Transplantations in Pediatric Acute Myeloid Leukemia: Prognostic Significance of Remission and Severe Sinusoidal Obstruction Syndrome2025
  3. 3Second autologous transplantation remains a valid consolidation option in patients with relapsed multiple myeloma: A report from the Latin American bone marrow transplantation group2025
  4. 4Comparable survival outcomes after myeloablative allogeneic stem cell transplantation in secondary and de novo Acute Myeloid Leukemia in first complete remission: A propensity Score–Matched study2025
  5. 5Allogeneic hematopoietic stem cell transplantation for myelofibrosis; Patterns, treatment and outcome after relapse and long-term follow up.2025