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October 2, 2025British Journal of HaematologyOpen Access

Outcomes after a second allogeneic haematopoietic stem cell transplant for relapsed paediatric acute myeloid leukaemia improved over time: A study from the EBMT Paediatric Diseases Working Party

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Authors

NBNimrod BuchbinderVMV. MichelADArnaud Dalissier

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Overview

Analysis reveals enhanced survival metrics in paediatric patients undergoing repeated transplant procedures, suggesting beneficial outcomes with specific conditions.

Key Points

  • Leukaemia-free survival improved significantly over time, with a 3-year rate reaching 34.3% for transplants from 2014-2022.
  • Overall survival rates also saw an enhancement of 10.1 percentage points for HSCT performed in the later period compared to earlier years.
  • Certain factors like remission pre-HSCT2 and later relapse led to better outcomes, highlighting specific patient criteria for successful treatment.
  • Mismatched unrelated donor scenarios adversely affected overall survival, emphasizing the importance of donor compatibility.

Cite This Study

Buchbinder et al. (2025) studied this question.

synapsesocial.com/papers/68de84bf5b556a9128e1bbd2https://doi.org/10.1111/bjh.70167
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