Multiple Hematopoietic Stem Cell Transplantations in Pediatric Acute Myeloid Leukemia: Prognostic Significance of Remission and Severe Sinusoidal Obstruction Syndrome
Retrospective analysis evaluates overall survival in pediatric AML patients post multiple HSCTs, indicating remission and severe SOS are critical prognostic factors.
Key Points
Achieving hematological complete remission before the second HSCT significantly improves overall survival.
Five-year overall survival after the second HSCT stands at 28.3% among patients, with severe sinusoidal obstruction syndrome worsening prognosis.
Retrospective, multicenter study of 49 pediatric patients with AML conducted over 19 years provides essential insights into outcome predictors.
Optimized pre-transplant strategies are crucial to reduce complications like severe SOS in young patients undergoing multiple HSCTs.