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December 8, 2025Blood

Comparable survival outcomes after myeloablative allogeneic stem cell transplantation in secondary and de novo Acute Myeloid Leukemia in first complete remission: A propensity Score–Matched study

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DFDan Feng

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Overview

Propensity score analysis shows comparable survival for sAML and de novo AML patients after allogeneic transplantation, suggesting broad outcomes.

Key Points

  • Overall survival was similar, with relapse incidence rates being statistically comparable in both sAML and de novo AML groups.
  • Analysis conducted using a propensity score-matched dataset from the Chinese Academy of Medical Sciences between 2013 and 2024.
  • Data on patient characteristics included Karnofsky Performance Status and comorbidity index to assess treatment effects and outcomes.
  • Findings support that both secondary and de novo AML may have equivalent prognostic outcomes post-transplantation.

Cite This Study

Dan Feng (2025) studied this question.

synapsesocial.com/papers/69362f484fa91c937236d726https://doi.org/10.1182/blood-2025-7741
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1T cell replete haploidentical transplantation compared to mismatched unrelated allogeneic transplantation with post-transplantation cyclophosphamide in patients with secondary acute myeloid leukemia in first complete remission: A study from the ALWP/EBMT2025
  2. 2Good report of secondary allogeneic hematopoietic stem cell transplantation in patients with refractory/relapsed Acute Myeloid Leukemia2025
  3. 3Young (35 years) matched sibling donors for allogeneic transplantation with post-transplantation cyclophosphamide in patients with secondary acute myeloid leukemia in first complete remission: A study from the ALWP/EBMT2025
  4. 4Better outcomes with haploidentical than matched sibling donors for adult AML patients allo-transplanted in CR with detectable MRD: A study from the global committee and the ALWP of the EBMT.2025 · 1 citations
  5. 5Impact of induction response and co-mutations on transplant outcomes in AML with myelodysplasia-related gene mutations: A multicenter retrospective study2025