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December 8, 2025BloodOpen Access

Second autologous transplantation remains a valid consolidation option in patients with relapsed multiple myeloma: A report from the Latin American bone marrow transplantation group

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Authors

GRGuillermina RemaggiMBMariano BerroARAlejandra Rocca

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Overview

Retrospective analysis shows second autologous hematopoietic cell transplantation significantly improves progression-free survival in multiple myeloma patients, indicating treatment efficacy.

Key Points

  • To evaluate the effectiveness of second autologous hematopoietic cell transplantation in relapsed multiple myeloma patients after first relapse.
  • Conducted a retrospective analysis of multiple myeloma patients who underwent second autologous hematopoietic cell transplantation.
  • Patients from 13 centers in Latin America were included from 2003-2024.
  • Primary outcome measured was progression-free survival defined from transplantation date.
  • 141 patients were analyzed; 4-year overall survival rate was 57.7%.
  • Median progression-free survival after second transplantation was 30.6 months.
  • Patients with extramedullary disease had a median progression-free survival of 9.9 months.

Cite This Study

Remaggi et al. (2025) studied this question.

synapsesocial.com/papers/693624dd4fa91c937236d18ehttps://doi.org/10.1182/blood-2025-5839
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Good report of secondary allogeneic hematopoietic stem cell transplantation in patients with refractory/relapsed Acute Myeloid Leukemia2025
  2. 2Comparable outcomes after autologous hematopoietic cell transplantation in T-cell lymphoma regardless of pre-transplant response: A key finding in resource-limited countries.2025
  3. 3In multiple myeloma patients, autologous stem cell transplants abrogate the difference of treating them with two or three drug combinations: Real world data from a single institution in a middle-income country.2025
  4. 4Operational cure in patients with newly diagnosed multiple myeloma after autologous stem cell transplantation: Long-term survivors and impact of induction regimens.2025
  5. 5Treatment Strategies of Acute Myeloid Leukemia Relapses after Allogeneic Stem Cell Transplantation: Evidence from the GITMO Nationwide Italian Registry2025 · 1 citations