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December 4, 2025Biomarker ResearchOpen Access

Mega-scale single-cell profiling reveals novel biomarkers associated with acute GvHD after allogeneic hematopoietic stem cell transplantation

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Authors

ZSZheng SongRDRegine J. DressECEmilia Czajkowski

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Overview

Analysis reveals novel biomarkers from graft-derived T cells in AML patients, suggesting new targets for risk stratification and treatment.

Key Points

  • MDGA1 and ADGRG1 are potential biomarkers associated with acute graft-versus-host disease.
  • Single-cell RNA sequencing profiled over 777,000 leukocytes from AML patients post-transplant.
  • Transplantation analysis highlights the importance of immune cell memory in patient outcomes.
  • Findings may enable improved risk stratification for alloHSCT and inform therapeutic strategies.

Cite This Study

Song et al. (2025) studied this question.

synapsesocial.com/papers/6930dc92ea1aef094cca2b1fhttps://doi.org/10.1186/s40364-025-00868-x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Single-cell transcriptional profiling identifies ADGRG1+ CD8 T cells as critical mediators of graft-versus-leukemia effect in AML relapse after haploidentical hematopoietic stem cell transplantation2025
  2. 2Impact CD34+ cell doses and allograft composition on acute graft-versus-host disease: A single-center prospective cohort study2025
  3. 3Monocyte-T cells crosstalk orchestrates early graft-versus-leukemia immunity in Acute Myeloid Leukemia patients after allogeneic transplantation2025
  4. 4In Vivo clonal dynamics of alloreactive CAR T cells reveal mechanisms limiting gvhd risk following allogeneic CAR T cell therapy2025
  5. 5Longitudinal multiproteomic analysis reveals persistent underlying inflammation in acute graft-versus-host disease patients responding to corticosteroid treatment2025