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December 8, 2025BloodOpen Access

Monocyte-T cells crosstalk orchestrates early graft-versus-leukemia immunity in Acute Myeloid Leukemia patients after allogeneic transplantation

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Authors

SHSha Hao

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Overview

Single-cell RNA sequencing reveals immune reconstitution roles in Acute Myeloid Leukemia, suggesting implications for T cell exhaustion and tumor immunity.

Key Points

  • Acute Myeloid Leukemia patients exhibited distinct immune reconstitution dynamics compared to aplastic anemia patients post-transplant.
  • Single-cell RNA sequencing showed significant upregulation of antigen presentation genes in T cells at 30 days after transplantation.
  • Observation of hyperactivated monocytes correlates with T cell exhaustion, implicating challenging graft-versus-leukemia effects.
  • Pharmacologic inhibition of Gal-9 could restore T cell functionality and reduce exhaustion, highlighting therapeutic opportunities.

Cite This Study

Sha Hao (2025) studied this question.

synapsesocial.com/papers/69362f514fa91c937236d938https://doi.org/10.1182/blood-2025-594
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Also Consider

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  1. 1Single-cell transcriptional profiling identifies ADGRG1+ CD8 T cells as critical mediators of graft-versus-leukemia effect in AML relapse after haploidentical hematopoietic stem cell transplantation2025
  2. 2Dynamics of leukemic blast and immune cell populations in Acute Myeloid Leukemia2025
  3. 3The Acute Myeloid Leukemia microenvironment is defined by ineffective immune surveillance despite the presence of activated, clonally-expanded CD8 T cells with preserved effector function2025
  4. 4Mega-scale single-cell profiling reveals novel biomarkers associated with acute GvHD after allogeneic hematopoietic stem cell transplantation2025 · 1 citations
  5. 5Integrative analysis of the interplay between peripheral immune landscape and leukemic blast adaptation in Acute Myeloid Leukemia2025