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December 8, 2025BloodOpen Access

Transcriptome sequencing of Hodgkin lymphoma Hodgkin and reed-stenberg cells reveals escape from NK cell recognition and an unfolded protein response

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Authors

MTMatthew TeaterJBJoshua BrodyAKAlexandra E. Kovach

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Overview

Transcriptome sequencing reveals altered NK cell recognition and unfolded protein response in Hodgkin lymphoma cells, suggesting immune evasion pathways.

Key Points

  • Hodgkin lymphoma cells exhibit immune evasion due to altered NK cell recognition mechanisms.
  • Significant upregulation of the unfolded protein response was found in Hodgkin and Reed-Sternberg cells.
  • Gene Set Enrichment Analysis highlighted new pathways associated with Hodgkin lymphoma.
  • Immunohistochemistry confirmed the distinct molecular profile of Hodgkin lymphoma compared to other B cell malignancies.

Cite This Study

Teater et al. (2025) studied this question.

synapsesocial.com/papers/69362f714fa91c937236e229https://doi.org/10.1182/blood-2025-3538
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Transcriptome sequencing of Hodgkin lymphoma Hodgkin and Reed-Stenberg cells reveals escape from NK cell recognition and an unfolded protein response2025
  2. 2Efferocytosis and M2 Macrophage Polarization Gene Expression Correlates With Relapsed and Refractory Classical Hodgkin Lymphoma Patients: A Multi‐Omic Analysis2025
  3. 3Morphology guided spatial transcriptomics to study topography of Hodgkin reed sternberg cells interaction with tumor microenvironment and its impact in defining risk of progression in classical Hodgkin lymphoma.2025
  4. 4Multimodal discovery of distinct tumor ecosystems for classic Hodgkin lymphoma2025
  5. 5Evaluation of STAT6 and PD-L1 expression in Hodgkin/reed-sternberg (HRS)-like cells in Hodgkin lymphoma-like Richter transformation arising in chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL)2025