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December 8, 2025BloodOpen Access

Evaluation of STAT6 and PD-L1 expression in Hodgkin/reed-sternberg (HRS)-like cells in Hodgkin lymphoma-like Richter transformation arising in chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL)

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Authors

YZYong ZhangYYin-HungGPGeraldine Pinkus

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Overview

Analysis shows immune evasion and PD-L1 expression impact outcomes in Richter transformation of CLL/SLL.

Key Points

  • To evaluate the expression of STAT6 and PD-L1 in Richter transformation of chronic lymphocytic leukemia/small lymphocytic lymphoma.
  • Conducted retrospective analysis of 19 cases of cHL-RT
  • Assessed STAT6 and PD-L1 expression by immunohistochemistry
  • Collected clinical characteristics, molecular and cytogenetic data
  • No cases had STAT6 expression; majority (76%) demonstrated PD-L1 expression
  • EBV positivity was found in 42% of cases, highlighting an association with Type II
  • 28% of patients died of disease within 3 years of diagnosis.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/69362f364fa91c937236d2e0https://doi.org/10.1182/blood-2025-5407
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Also Consider

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  1. 1Transcriptome sequencing of Hodgkin lymphoma Hodgkin and reed-stenberg cells reveals escape from NK cell recognition and an unfolded protein response2025
  2. 2Morphology guided spatial transcriptomics to study topography of Hodgkin reed sternberg cells interaction with tumor microenvironment and its impact in defining risk of progression in classical Hodgkin lymphoma.2025
  3. 3Richter Transformation in Chronic Lymphocytic Leukemia: Current Treatment Challenges and Evolving Therapies2025 · 3 citations
  4. 4Multimodal discovery of distinct tumor ecosystems for classic Hodgkin lymphoma2025
  5. 5Editorial: Refractory and relapsed hemophagocytic lymphohistiocytosis in pediatric population: targeted therapy2025