Efferocytosis and M2 Macrophage Polarization Gene Expression Correlates With Relapsed and Refractory Classical Hodgkin Lymphoma Patients: A Multi‐Omic Analysis
Multi-Omic analysis reveals that efferocytosis and M2 macrophage polarization correlate with treatment outcomes in classical Hodgkin lymphoma, indicating potential immune pathways.
Key Points
Increased M2 macrophage proportions correlate with poorer treatment responses in classical Hodgkin lymphoma, signifying immune microenvironment dynamics.
A 37-gene HRS cell signature identified Hodgkin-Reed Sternberg cells in single-cell RNA sequencing data, facilitating precise cell identification and analysis.
Differential gene expression revealed that high efferocytosis and M2 gene expression relate to poor treatment outcomes, emphasizing possible therapeutic targets.
Ridge regression models predicted treatment response with an accuracy (AUC) of 0.87, integrating gene expression profiles and cellular proportions to enhance predictive capability.