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December 8, 2025Blood

Morphology guided spatial transcriptomics to study topography of Hodgkin reed sternberg cells interaction with tumor microenvironment and its impact in defining risk of progression in classical Hodgkin lymphoma.

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Authors

TLTanja LazicRVRiccardo ValliETErica Travaglino

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Overview

Integrated analysis uncovers HRS cells' interactions and immunosuppression in classical Hodgkin lymphoma, impacting progression-free survival.

Key Points

  • Significant differences in HRS cell morphology were identified between relapsed and non-relapsed classical Hodgkin lymphoma cases, highlighting critical tumor microenvironment interactions.
  • Digital barcoding analysis showed correlation of CCL17 and CXCL9 with patient outcomes, indicating roles of immune escape in disease progression analysis.
  • Observational study employed morphology-guided spatial transcriptomics to examine immune-related gene expression in a cohort of untreated classical Hodgkin lymphoma patients.
  • May enable identification of non-tumoral B-cells as potential biomarkers for risk stratification in advanced Hodgkin lymphoma cases.

Cite This Study

Lazic et al. (2025) studied this question.

synapsesocial.com/papers/69362f5a4fa91c937236db1ehttps://doi.org/10.1182/blood-2025-5315
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Multimodal discovery of distinct tumor ecosystems for classic Hodgkin lymphoma2025
  2. 2Transcriptome sequencing of Hodgkin lymphoma Hodgkin and reed-stenberg cells reveals escape from NK cell recognition and an unfolded protein response2025
  3. 3Efferocytosis and M2 Macrophage Polarization Gene Expression Correlates With Relapsed and Refractory Classical Hodgkin Lymphoma Patients: A Multi‐Omic Analysis2025
  4. 4Tumor microenvironment differences between diagnostic and relapsed classic Hodgkin lymphoma revealed by scRNA-seq2025 · 3 citations
  5. 5Spatial transcriptomic analysis of chronic lymphocytic leukemia lymph nodes reveals tumor microenvironment evolution during disease progression2025