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December 8, 2025BloodOpen Access

Multimodal discovery of distinct tumor ecosystems for classic Hodgkin lymphoma

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Authors

TFTimothy FlerlageSYSheren YounesOSOscar Silva

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Overview

Multimodal analysis reveals distinct immune cell states and extracellular matrix roles in classic Hodgkin lymphoma, suggesting targeted therapies.

Key Points

  • Diverse immune cell states were identified in the tumor microenvironment, impacting disease progression.
  • Single cell RNA-seq enabled profiling of 44,769 cells across various cases, enhancing tumor characterization.
  • Machine-learning framework EcoTyper revealed distinct Hodgkin lymphoma ecotypes linked to EBV status.
  • Association of specific cell states with freedom from progression highlights the need for targeted treatments.

Cite This Study

Flerlage et al. (2025) studied this question.

synapsesocial.com/papers/69362f4b4fa91c937236d76dhttps://doi.org/10.1182/blood-2025-1783
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Morphology guided spatial transcriptomics to study topography of Hodgkin reed sternberg cells interaction with tumor microenvironment and its impact in defining risk of progression in classical Hodgkin lymphoma.2025
  2. 2Transcriptome sequencing of Hodgkin lymphoma Hodgkin and reed-stenberg cells reveals escape from NK cell recognition and an unfolded protein response2025
  3. 3Efferocytosis and M2 Macrophage Polarization Gene Expression Correlates With Relapsed and Refractory Classical Hodgkin Lymphoma Patients: A Multi‐Omic Analysis2025
  4. 4Transcriptome sequencing of Hodgkin lymphoma Hodgkin and Reed-Stenberg cells reveals escape from NK cell recognition and an unfolded protein response2025
  5. 5Tumor microenvironment differences between diagnostic and relapsed classic Hodgkin lymphoma revealed by scRNA-seq2025 · 3 citations