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December 8, 2025Blood

Psychiatric comorbidities and the mortality paradox in sickle cell disease: A national inpatient analysis

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Authors

BFBolivia FernandesASAmara SofiaMMMichael Maroules

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Overview

National inpatient analysis reveals psychological comorbidities impact hospitalization and outcomes in sickle cell disease.

Key Points

  • In-hospital mortality decreased significantly with major depressive disorder, showing an odds ratio of 0.60.
  • Among 105,938 hospitalizations, 11.4% had major depressive disorder, while 1.5% had alcohol use disorder.
  • Logistic modeling assessed mortality risk, adjusting for demographics and comorbidity burden using Elixhauser index.
  • This study suggests integrating mental health services may improve outcomes in sickle cell disease hospitalizations.

Cite This Study

Fernandes et al. (2025) studied this question.

synapsesocial.com/papers/69362f714fa91c937236e216https://doi.org/10.1182/blood-2025-4447
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Also Consider

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  1. 1Influence of cardiovascular co-morbidities on the in-hospital mortality among patients with sickle cell crisis2025
  2. 2SUBSTANCE AND ALCOHOL USE DISORDERS IN CROHN’S DISEASE FLARE HOSPITALIZATIONS: PREVALENCE, OUTCOMES AND RACIAL DISPARITIES IN A NATIONAL COHORT2026
  3. 3Association between comorbid depression and antidepressant adherence with adherence to disease-modifying therapies in patients with sickle cell disease in Texas Medicaid2025 · 1 citations
  4. 4Social isolation and patient-reported and healthcare utilization in adults with sickle cell disease2025
  5. 5The national burden of opoid use disorder on hospital outcomes in sickle cell disease: A database review and analysis2025