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December 8, 2025BloodOpen Access

The national burden of opoid use disorder on hospital outcomes in sickle cell disease: A database review and analysis

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Authors

SPSindhu C PokhriyalSASai Anusha AkellaTOThein Hlaing Oo

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Overview

Analysis uncovers opioid use disorder influences acute chest syndrome and healthcare outcomes in sickle cell disease patients, suggesting critical intervention needs.

Key Points

  • OUD was significantly associated with increased odds of acute chest syndrome in SCD patients.
  • Among 928,485 SCD hospitalizations, 5.8% had comorbid OUD, influencing care quality and costs.
  • Linear regression indicated OUD increased hospital charges by over $6,400 and extended length of stay by 1.65 days.
  • Findings highlight the essential need for early identification and targeted strategies for OUD in SCD treatment.

Cite This Study

Pokhriyal et al. (2025) studied this question.

synapsesocial.com/papers/69362f7d4fa91c937236e49dhttps://doi.org/10.1182/blood-2025-1174
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Correlation between outpatient opioid dosage and hospital visits in sickle cell disease patients2025
  2. 2Patterns of Opioid Utilization and Aberrant Opioid-Related Behaviors (AORB) in Pediatric Sickle Cell Anemia Patients: A Systematic Review2026
  3. 3Preoperative Opioid Use Disorder Predicts Prolonged Ventilation, Central Line Placement, and Major Anesthesiology Complications After ACDF Surgery: A Big Data Analysis of 180,000 Cases2025
  4. 4Psychiatric comorbidities and the mortality paradox in sickle cell disease: A national inpatient analysis2025
  5. 5Addressing institutional barriers in sickle cell pain management: A resident-led quality improvement study2025