Association between comorbid depression and antidepressant adherence with adherence to disease-modifying therapies in patients with sickle cell disease in Texas Medicaid
Retrospective analysis shows that adherence to L-glutamine and antidepressants affects treatment adherence in sickle cell disease, suggesting better mental health support is needed.
Key Points
Twenty-two percent of patients with sickle cell disease were found to have comorbid anxiety, highlighting a significant overlap between these conditions.
Patients with sickle cell disease and comorbid depression showed notably lower adherence rates for disease-modifying therapies compared to those without depression.
Logistic regression analysis revealed treatment adherence is significantly influenced by both comorbid depression and the number of vaso-occlusive crises per patient.
Ongoing treatment for anxiety and depression may improve overall adherence rates to important therapies for sickle cell disease.