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December 8, 2025BloodOpen Access

Disruption of intestinal homeostasis reflected by DAO and microbiota alterations in gvhd post-HSCT.

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Authors

SSShotaro ShiratoMKMasayoshi Kobune

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Overview

Retrospective analysis reveals that microbiota changes and intestinal barrier disruptions are linked to graft-versus-host disease after hemopoietic stem cell transplantation.

Key Points

  • Marked shifts in microbiota diversity were observed in patients developing graft-versus-host disease, highlighting the significance of these changes in association with the illness.
  • Next-generation sequencing revealed marked depletion of butyrate-producing bacteria post-transplantation, implicating their loss in invoking intestinal dysbiosis and potential GVHD.
  • Analysis of intestinal barrier function through plasma DAO activity showcased notable inter-individual variability, which was affected by the onset of graft-versus-host disease.
  • Serial monitoring of microbiota changes provides valuable insights, emphasizing the interplay between intestinal health and graft-versus-host disease post-HSCT.

Cite This Study

Shirato et al. (2025) studied this question.

synapsesocial.com/papers/69362f714fa91c937236e208https://doi.org/10.1182/blood-2025-2457
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Microbiome Signature Linked to the Development and Management of Intestinal Acute Graft-versus-Host Disease in Pediatric Patients Undergoing Hematopoietic Stem Cell Transplantation2025
  2. 2Microbiome and cytokine features are associated with graft-versus-host disease incidence in allogeneic hematopoietic cell transplantation patients2025
  3. 3Longitudinal and integrated analysis of oral and stool microbiome in allogeneic hematopoietic cell transplantation recipients.2025
  4. 4Persistent microbiome dysbiosis following hematopoietic cell transplantation: Gut GvHD as the most severe manifestation of microbial disruption2025 · 1 citations
  5. 5Gut microbiota recovery via butyrate supplementation prevents acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation2025