December 8, 2025BloodOpen Access

Persistent microbiome dysbiosis following hematopoietic cell transplantation: Gut GvHD as the most severe manifestation of microbial disruption

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Observational analysis identifies gut GvHD as a severe manifestation of microbiome disruption in transplant patients, suggesting a critical link.

Transplant patients showed significant gut microbiome disruption with diversity remaining low at only 3% of control levels.
Among patients with GvHD, those with gut involvement had a markedly lower microbiome diversity compared to other categories.
Analysis was performed using mixed-effects models on 385 fecal samples across multiple time points post-transplant.
These findings highlight the urgent need for developing microbiome interventions targeting gut GvHD in transplant patients.

Hashem et al. (2025) studied this question.

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December 8, 2025BloodOpen Access

View Full Paper

Ask AI

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Authors

Observational analysis identifies gut GvHD as a severe manifestation of microbiome disruption in transplant patients, suggesting a critical link.

Transplant patients showed significant gut microbiome disruption with diversity remaining low at only 3% of control levels.
Among patients with GvHD, those with gut involvement had a markedly lower microbiome diversity compared to other categories.
Analysis was performed using mixed-effects models on 385 fecal samples across multiple time points post-transplant.
These findings highlight the urgent need for developing microbiome interventions targeting gut GvHD in transplant patients.

Hashem et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark