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December 8, 2025BloodOpen Access

Gut microbiota recovery via butyrate supplementation prevents acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation

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Authors

JWJong-Ho Won

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Overview

Prospective study demonstrates oral sodium butyrate supplementation lowers acute graft-versus-host disease incidence in allo-HSCT recipients, suggesting benefits for microbiota diversity.

Key Points

  • Butyrate supplementation significantly reduced the cumulative incidence of acute graft-versus-host disease in transplant recipients.
  • Patients receiving sodium butyrate showed improved microbiota diversity recovery by day +100 post-transplant.
  • Observational analysis highlighted the immunomodulatory effects of butyrate as a short-chain fatty acid.
  • Caution is warranted as the study calls for randomized trials to further confirm these promising results.

Cite This Study

Jong-Ho Won (2025) studied this question.

synapsesocial.com/papers/69362f694fa91c937236def3https://doi.org/10.1182/blood-2025-4226
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Gentamicin alleviates intestinal graft-versus-host disease by modulating butyrate-associated gut microbiota2025
  2. 2Microbiome Signature Linked to the Development and Management of Intestinal Acute Graft-versus-Host Disease in Pediatric Patients Undergoing Hematopoietic Stem Cell Transplantation2025
  3. 3Alterations in the gut microbiome and the association of butyrate producers with progression-free survival in multiple myeloma patients undergoing autologous stem cell transplantation2025
  4. 4Microbiome and cytokine features are associated with graft-versus-host disease incidence in allogeneic hematopoietic cell transplantation patients2025
  5. 5The role of microbial metabolites in fecal microbiota transplantation in patients with acute gvhd of the gut2025