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December 8, 2025Blood

Peripheral plasmablast expansion as a predictor and therapeutic target in chronic GVHD

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Authors

KHKatharina HabenichtAHAndreas HiergeistMFMatthias Fante

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Overview

Observational analysis identifies elevated plasmablasts and somatic mutations in cGVHD, indicating potential therapy targets.

Key Points

  • Elevated frequencies of plasmablasts predicted chronic GVHD onset, with 7.0% vs 1.9% of CD19+ cells at diagnosis.
  • Somatic mutations were significantly noted in expanded plasmablasts representative of cGVHD.
  • First-line therapy with steroids reduced severity and plasmablast frequencies, establishing a new treatment approach.
  • Microbiome interactions were suggested by IgA+ plasmablasts recognizing specific gut bacteria, revealing intricate relationships.

Cite This Study

Habenicht et al. (2025) studied this question.

synapsesocial.com/papers/69362f634fa91c937236ddf4https://doi.org/10.1182/blood-2025-4245
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  3. 3High donor regulatory B cells (Bregs) and their rapid recovery are associated with protection from the development of acute graft-versus-host disease (aGVHD) following allogeneic hematopoietic stem cell transplantation.2025 · 1 citations
  4. 4Thymic dysfunction promotes the emergence of pathogenic peripheral CD4⁺CD8⁺ T cells and induces tissue injury in acute gvhd2025
  5. 5Donor and recipient age-related differences in immunological reconstitution affect development of chronic graft-versus-host disease2025