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December 8, 2025BloodOpen Access

Stage 0+ lower gastrointestinal (LGI) acute graft-versus-host disease (aGVHD) is associated with high response to non-systemic treatment, low incidence of moderate to severe chronic graft-versus-host disease (cGVHD) and low non-relapse mortality (NRM)

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Authors

NONatalia Tijaro OvalleSBSamantha BrownIGIlan Goldstein

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Overview

Analysis reveals favorable clinical outcomes in patients with stage 0+ acute graft-versus-host disease, suggesting the need for specific recognition in assessment frameworks.

Key Points

  • High response to non-systemic treatment in patients with acute graft-versus-host disease, indicating positive clinical outcomes.
  • The cumulative incidence function shows low rates of chronic graft-versus-host disease in stage 0+ patients compared to higher stages.
  • Use of budesonide as a primary treatment illustrates a distinct therapeutic approach for mild acute graft-versus-host disease.
  • Findings highlight the importance of recognizing stage 0+ LGI aGVHD in future graft-versus-host disease grading systems.

Cite This Study

Ovalle et al. (2025) studied this question.

synapsesocial.com/papers/69362f714fa91c937236e19chttps://doi.org/10.1182/blood-2025-2463
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Grade I acute graft-vs-host disease: Treat or not?2025
  2. 2Oral chronic graft-versus-host disease (cGVHD) as a potential clinical marker of the graft-versus-leukemia (GVL) effect in allogeneic hematopoietic stem cell transplantation: A prospective single-center study2025
  3. 3Chronic GVHD Consortium CATCH Study: Incidence, initial presentation and risk factors for chronic GVHD development2026
  4. 4Longitudinal multiproteomic analysis reveals persistent underlying inflammation in acute graft-versus-host disease patients responding to corticosteroid treatment2025
  5. 5Complex endoscopic diagnosis of the gastrointestinal form of acute graft-versus-host disease in children who underwent allogeneic hematopoietic stem cell transplantation. Single-center study2025