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December 8, 2025BloodOpen Access

Transcriptional programming by GATA3 regulates CD4+ T cell GM-CSF production in the gastrointestinal tract during graft versus host disease

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Authors

JFJonathan FlorentinRSRavi K. Shah

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Overview

Analysis reveals GATA3 regulates cytokine production in CD4+ T cells, suggesting its pivotal role in graft versus host disease.

Key Points

  • GATA3 regulates GM-CSF production in CD4+ T cells during graft versus host disease, influencing pathogenicity.
  • Reduced GVHD mortality observed in mice lacking Batf or Bhlhe40 with CD4+ GM-CSF+ T cells present.
  • Observational analysis identifies transcription factors crucial for CD4+ GM-CSF+ T cell regulation in the gastrointestinal tract.
  • Impacts highlight the importance of GATA3 in maintaining immunological balance in graft versus host disease.

Cite This Study

Florentin et al. (2025) studied this question.

synapsesocial.com/papers/69362f6c4fa91c937236dfb2https://doi.org/10.1182/blood-2025-158
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Also Consider

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  1. 1Galectin-3 in host murine models lessens the severity of graft-versus-host disease by preserving intestinal stem cells irrespective of gut microbiota composition2025
  2. 2Overexpression of CD103 on regulatory T cells mitigates acute graft-versus-host disease via promotion of tolerogenic dendritic cell networks2025 · 1 citations
  3. 3IFNγ-driven MHC class II expression by intestinal epithelial cells dictates local cytolytic Th1 cell differentiation and intestinal stem cell loss2025
  4. 4TIM3-Galectin9 axis drives CSF-1R–independent senescent macrophage and TSCM crosstalk in chronic graft-versus-host disease2025
  5. 5Thymic dysfunction promotes the emergence of pathogenic peripheral CD4⁺CD8⁺ T cells and induces tissue injury in acute gvhd2025