Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025Blood

Overexpression of CD103 on regulatory T cells mitigates acute graft-versus-host disease via promotion of tolerogenic dendritic cell networks

View Full Paper
Ask AI
Bookmark
Share

Authors

MTMehrdad Hefazi TorghabehOSOlivia SirpillaJFJennifer M. Feigin

Discussion

Loading...

Member takes

Overview

Transduced Tregs improved survival and reduced GVHD severity in a murine model, suggesting a role for tolerogenic dendritic cells.

Key Points

  • CD103high regulatory T cells significantly decreased graft-versus-host disease severity and mortality.
  • In vivo studies showed improved clinical scores and immune responses across multiple organs.
  • Assessment utilized single-cell RNA sequencing, revealing altered immune cell communication and function.
  • Enhancing CD103 has potential implications in managing transplant-related complications effectively.

Cite This Study

Torghabeh et al. (2025) studied this question.

synapsesocial.com/papers/69362f514fa91c937236d956https://doi.org/10.1182/blood-2025-587
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Transcriptional programming by GATA3 regulates CD4+ T cell GM-CSF production in the gastrointestinal tract during graft versus host disease2025
  2. 2Galectin-3 in host murine models lessens the severity of graft-versus-host disease by preserving intestinal stem cells irrespective of gut microbiota composition2025
  3. 3CD8+hla-DR+CD27+ t cells define a population of naturally occurring regulatory precursors in humans2025 · 1 citations
  4. 4Liver-targeted delivery of bioengineered induced tregs via nanoparticles prevents and treats acute gvhd2025 · 1 citations
  5. 5Monocarboxylate transporter 1 deficient donor T cells rewire metabolism and ameliorate aGVHD lethality2025