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December 8, 2025Blood

Galectin-3 in host murine models lessens the severity of graft-versus-host disease by preserving intestinal stem cells irrespective of gut microbiota composition

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Authors

NNNour NassourEGEduardo Cortes GomezJWJianmin Wang

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Overview

Observational analysis shows galectin-3 influences graft-versus-host disease severity in murine models, suggesting impact on intestinal stem cells.

Key Points

  • Survival rates were significantly lower in galectin-3 deficient mice compared to wild type by day 60 after hematopoietic cell transplantation.
  • Distinct gut microbiome profiles correlated with higher graft-versus-host disease severity in mice lacking galectin-3.
  • Analysis of intestinal tissue revealed decreased goblet and enteroendocrine cell markers related to galectin-3 deficiency in the gut environment.
  • Alterations in gut microbiota due to antibiotic treatment worsened graft-versus-host disease and affected survival outcomes in studied mice.

Cite This Study

Nassour et al. (2025) studied this question.

synapsesocial.com/papers/69362f574fa91c937236daadhttps://doi.org/10.1182/blood-2025-4083
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