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December 8, 2025Blood

TIM3-Galectin9 axis drives CSF-1R–independent senescent macrophage and TSCM crosstalk in chronic graft-versus-host disease

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Authors

FTFengjuan TianRWRui WangQSQingxiao Song

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Overview

Observational analysis reveals interactions driving chronic graft-versus-host disease in patients, indicating novel therapeutic targets.

Key Points

  • TIM3-Galectin9 axis drives interaction between macrophages and stem-like memory T cells in cGVHD.
  • Key findings show elevated levels of IL-6 and IL-1β in macrophages from cGVHD skin lesions.
  • Analysis using single-cell RNA sequencing identified CSF-1R–independent macrophage populations in chronic graft-versus-host disease.
  • Therapeutic targeting of TIM3-Galectin9 may improve outcomes for patients resistant to standard CSF-1R therapies.

Cite This Study

Tian et al. (2025) studied this question.

synapsesocial.com/papers/69362f574fa91c937236daafhttps://doi.org/10.1182/blood-2025-4085
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1CSF-1R+ macrophages orchestrate human skin chronic graft-versus-host disease2025
  2. 2M1 macrophage and Treg crosstalk mapping at single-cell resolution in mucosal chronic graft-versus-host disease 39402025
  3. 3Targeting hedgehog signaling/KL4-dependent M2 macrophage polarization for treatment of chronic graft-versus-host diseases and tissue fibrosis2025
  4. 4Genomic Analysis Defines Increased Circulating, Leukemia-Induced Macrophages That Promote Immune Suppression in Mouse Models of FGFR1-Driven Leukemogenesis2025
  5. 5Transcriptional programming by GATA3 regulates CD4+ T cell GM-CSF production in the gastrointestinal tract during graft versus host disease2025