What type of study is this?

This is a Animal Study study (also classified as: In Vitro Study).

December 8, 2025Blood

Dnmt3a-mutant hematopoietic stem cells generate alloreactive T cells with graft vs host disease and graft vs leukemia effects

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Observational analysis reveals graft vs host disease in T cells from Dnmt3a-mutant hematopoietic stem cells, indicating heightened inflammation.

Graft vs host disease develops early in CD4+ T cell recipients from Dnmt3aR878H/+ mice, worsening clinical signs early compared to controls.
Increased inflammatory cytokines including IL-6 and CCL5 were observed in Dnmt3aR878H/+ mice after ~24 weeks of mutant induction.
Adoptive transfer demonstrates Dnmt3aR878H/+ T cells show enhanced alloreactivity and mediate potent graft vs leukemia effects in models.
Findings underscore the role of Dnmt3a mutations in driving T cell-mediated GVHD and enhancing anti-leukemic activity.

Engelken et al. (2025) studied this question.

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December 8, 2025Blood

View Full Paper

Ask AI

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Authors

Observational analysis reveals graft vs host disease in T cells from Dnmt3a-mutant hematopoietic stem cells, indicating heightened inflammation.

Graft vs host disease develops early in CD4+ T cell recipients from Dnmt3aR878H/+ mice, worsening clinical signs early compared to controls.
Increased inflammatory cytokines including IL-6 and CCL5 were observed in Dnmt3aR878H/+ mice after ~24 weeks of mutant induction.
Adoptive transfer demonstrates Dnmt3aR878H/+ T cells show enhanced alloreactivity and mediate potent graft vs leukemia effects in models.
Findings underscore the role of Dnmt3a mutations in driving T cell-mediated GVHD and enhancing anti-leukemic activity.

Engelken et al. (2025) studied this question.

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