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December 8, 2025BloodOpen Access

DNMT3A-driven clonal hematopoiesis permits colitis-associated tumorigenesis by promoting innate immune tolerance

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Authors

PKPrabhjot KaurAMAnnalisse MckeeJSJixiu Shan

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Overview

Analysis shows enhanced tumor immune microenvironment in cancer driven by DNMT3A clonal hematopoiesis, suggesting strategies against inflammation-related cancers.

Key Points

  • Increased pro-oncogenic activity was observed in Dnmt3a-driven clonal hematopoiesis, enhancing tumor growth in a colitis model.
  • Monocytic and macrophage infiltration in the tumor immune microenvironment was more pronounced with Dnmt3a mutations.
  • The study employed a mouse model to explore the effects of Dnmt3a loss on inflammatory responses and tumor formation.
  • Targeting immune tolerance mechanisms in Dnmt3a-CH could offer new strategies for preventing inflammation-linked cancers.

Cite This Study

Kaur et al. (2025) studied this question.

synapsesocial.com/papers/69362f4b4fa91c937236d81ehttps://doi.org/10.1182/blood-2025-3170
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Dnmt3a-mutant hematopoietic stem cells generate alloreactive T cells with graft vs host disease and graft vs leukemia effects2025
  2. 2Clonal hematopoiesis drives T cell dysregulation and immune remodeling revealed by GWAS-based mendelian randomization and single-cell transcriptomics2025
  3. 3Bone marrow environmental alterations underlie proliferative clonal expansion in clonal hematopoiesis2025
  4. 4Conditional knockouts demonstrate that the autoimmune-associated nuclease DNAse1L3 regulates tumor control by radiation therapy in preclinical models 32342025
  5. 5Ligature-induced periodontitis promotes Dnmt3a R878H-driven clonal hematopoiesis2026 · 1 citations