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December 8, 2025BloodOpen Access

Clonal hematopoiesis drives T cell dysregulation and immune remodeling revealed by GWAS-based mendelian randomization and single-cell transcriptomics

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Authors

RQRichard QinSKShivani KapadiaKPKernyu Park

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Overview

Mendelian randomization reveals clonal hematopoiesis impacts leukemia and cardiovascular disease through T cell dysregulation.

Key Points

  • Clonal hematopoiesis was causally linked to increased counts of monocytes and dysregulated regulatory T cells.
  • Mendelian randomization analyses utilized data from the UK Biobank and Sardinian cohort to evaluate immune traits.
  • Single-cell RNA sequencing identified shifts in T and B cell populations in subjects with clonal hematopoiesis mutations.
  • These findings suggest clonal hematopoiesis promotes a proinflammatory immune state, heightening graft-versus-host disease risk.

Cite This Study

Qin et al. (2025) studied this question.

synapsesocial.com/papers/69362f604fa91c937236dd56https://doi.org/10.1182/blood-2025-1396
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