Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025Blood

Identification of CD4+ T cells targeting DM-sensitive antigens presented on mismatched HLA-DP alleles, as mediators of a selective graft-versus-leukemia effect.

View Full Paper
Ask AI
Bookmark
Share

Authors

KKKlaus KornKGKatharina GötzHBHeiko Bruns

Discussion

Loading...

Member takes

Overview

Observational analysis identified T cells targeting DM-sensitive antigens in hematopoietic stem cell transplantation, suggesting reduced graft-versus-host disease risk.

Key Points

  • T cells targeting DM-sensitive antigens may effectively eliminate malignant hematopoietic cells without causing graft-versus-host disease.
  • Of 105 T-cell clones, 79 targeted DM-sensitive antigens, indicating a distinct recognition profile based on HLA-DP mismatches.
  • Assessment using T-cell receptor sequencing demonstrated functionality of engineered T cells expressing specific receptors against target antigens.
  • Extended cytokine analysis revealed activation markers including Granzyme A, Granzyme B, and the cytokine IL-6, associated with T-cell activity.

Cite This Study

Korn et al. (2025) studied this question.

synapsesocial.com/papers/69362f694fa91c937236df0ehttps://doi.org/10.1182/blood-2025-4235
View Full Paper
Ask AI
Bookmark
Share