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December 8, 2025BloodOpen Access

Screening for clonal hematopoiesis in patients with β-hemoglobinopathies who are candidates to transplant approaches

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Authors

RRRabah RedjoulFBFlorence Beckerich

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Overview

Prospective screening reveals clonal hematopoiesis and its link to TP53 mutations in Sickle Cell Disease patients, indicating the need for improved pre-transplant molecular profiling.

Key Points

  • Clonal hematopoiesis was identified in 20% of Sickle Cell Disease patients screened for pre-transplant evaluation.
  • Patients with high-risk TP53 mutations correlate with increased pre-transplant myeloid malignancies risk, emphasizing need for molecular profiling.
  • Prospective screening using targeted high-throughput panels identified somatic mutations before transplant decision-making.
  • Findings highlight the importance of pre-transplant molecular profiling for better outcome predictions in hematopoietic cell transplants.

Cite This Study

Redjoul et al. (2025) studied this question.

synapsesocial.com/papers/69362f5d4fa91c937236dc81https://doi.org/10.1182/blood-2025-534
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sickle cell disease is associated with early-onset clonal hematopoiesis involving DNA damage response pathway mutations2025 · 4 citations
  2. 2Intermediate and high-risk clonal hematopoiesis in germline predisposition families2025
  3. 3Evaluating the efficacy and safety of gene therapy in transfusion-dependent β-thalassemia: A focus on hemolysis improvement and clonal hematopoiesis monitoring2025 · 1 citations
  4. 4Clonal Hematopoiesis and Outcomes After High-Dose Chemotherapy and Autologous Stem Cell Transplantation in Patients with AML, Myeloma, and Lymphoma2025 · 2 citations
  5. 5Impact of pre-transplant bone marrow cellularity and fibrosis on post-transplant outcomes in sickle cell disease2025