Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 8, 2025BloodOpen Access

Biomarkers of ineffective erythropoiesis in patients with sickle cell anemia, at baseline and while treated with hydroxyurea, in comparison to patients with other iron-loading red cell disorders

View Full Paper
Ask AI
Bookmark
Share

Authors

RWRussell E. WareCincinnati Children's Hospital Medical Center

Discussion

Loading...

Member takes

Implication

Evaluation of iron and ineffective erythropoiesis biomarkers in sickle cell anemia patients while on hydroxyurea indicates improved iron regulation with treatment.

Key Points

  • Sickle cell anemia patients show significantly lower hepcidin/ferritin ratios, indicating iron dysregulation.
  • Hydroxyurea treatment improved the hepcidin/ferritin ratio in SCA, suggesting better iron management over time.
  • Assessment included biomarkers like erythroferrone and soluble transferrin receptor and dysregulation linked to hemoglobin levels.
  • Findings highlight the role of hydroxyurea in managing ineffective erythropoiesis and reducing iron overload in patients.

Cite This Study

Russell E. Ware (2025) studied this question.

synapsesocial.com/papers/69362f574fa91c937236dad7https://doi.org/10.1182/blood-2025-4686
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Iron deficiency limits hydroxyurea-induced fetal hemoglobin and clinical efficacy in sickle cell disease2025
  2. 2Biomarkers of ineffective erythropoiesis in patients with transfusion- dependent thalassemia2025 · 1 citations
  3. 3Oxidative stress and hemoglobin-c denaturation drive hemoglobin SC pathophysiology and can be ameliorated by antioxidants and hydroxyurea2025
  4. 4Real-world comparative effects of curative and disease-modifying therapies on ineffective erythropoiesis in beta-thalassemia2025
  5. 5Hemoglobin SC disease: Clinical analysis from the Georgia comprehensive sickle cell center at grady memorial hospital, Atlanta, Georgia.2025