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December 8, 2025Blood

Hemoglobin SC disease: Clinical analysis from the Georgia comprehensive sickle cell center at grady memorial hospital, Atlanta, Georgia.

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Authors

AAA.A. AjayiRFRoss M. Fasano

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Overview

Retrospective study evaluates complications and treatment response of HbSC in adults, suggesting distinct management needs.

Key Points

  • Evaluate clinical manifestations, treatment response, and complications in adults with HbSC disease.
  • IRB-approved retrospective study at Georgia Comprehensive Sickle Cell Center
  • Included adults with HbSC confirmed by electrophoresis from 2015-2025
  • Analyzed demographics, comorbidities, laboratory values, opioid use and hospitalizations
  • Statistical analysis with t-tests, chi-square, and multivariate regression
  • Cohort of 303 patients with 55.8% having hospitalization
  • Major complications included avascular necrosis in 40.9% and retinopathy in 40.3%
  • Hydroxyurea utilized in 19.1% of patients showing mild biological effects
  • Retinopathy risk decreased in those with ferritin <50 ng/mL, although not statistically significant
  • Strong association observed between acute chest syndrome and venous thromboembolism risk

Cite This Study

Ajayi et al. (2025) studied this question.

synapsesocial.com/papers/693624d44fa91c937236cfb7https://doi.org/10.1182/blood-2025-6533
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hemoglobin S beta thalessemia plus: Clinical analysis from the Georgia comprehensive sickle cell center at grady memorial hospital, Atlanta, Georgia.2025
  2. 2Real-world effectiveness and safety of hydroxyurea in adults with hemoglobin SC disease: A retrospective cohort study in Quebec, Canada2025
  3. 3Improvement of sickle cell disease care mitigates the healthcare utilization induced by increased prevalence: Experience of a tertiary pediatric center2025
  4. 4PO85 | Acute retinal ischemia in hemoglobin SC disease: a case report and review of the literature2025
  5. 5Systematic intensification of red cell exchange with hydroxyurea decreased the transfusion burden in patients with sickle cell disease: A single-center retrospective cohort study2025 · 1 citations